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KMID : 0356419960140010043
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Journal of Korean Andrology
1996 Volume.14 No. 1 p.43 ~ p.48
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Preventive Effect of Oral Ketoconazole on Postoperative Penile Erection
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Abstract
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The natural in patients undergoing penile surgery can be painful and may interfere with wound healing. The administration of ketoconazole, an inhibitor of testosterone synthesis was evaluated to determine whether it prevented postoperative penile
erection in 20 consecutive patients undergoing penile or urethral surgery. The drug was administered orally in a dose of 1200mg/day to adults and 3mg/kg per day to children for 7 days starting the day before surgery. Ten other patients received a
placebo. Nineteen patients receiving ketoconazole experienced no postoperative penile erection, and 1 patient had mild penile pain due to nocturnal and morning penile erection. Five patients revealed elevated serum concentrations of aspartate
aminotransferase for a mean of 3 days during ketoconazole therapy but recovered with drug discontinuation. Serum testosterone levels fell to 42.1 + 12.1% (SD) and 5.3 + 2.7% of baseline at 24 and 48 hours of drug administration, respectively, and
returned to 90.4 + 8.1% of baseline in 24 hours with discontinuation. Serum estradiol concentrations were slightly elevated at 24 and 48 hours of therapy but returned to the normal range within 24 hours with discontinuation. The patients in the
placebo
group had painful erections but showed no remarkable findings of liver function or serum hormones. Oral ketoconazole is a reliable method of inhibiting postoperative erection in patients undergoing penile surgery.
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KEYWORD
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